Biomedical Assets

Biomedical Assets

Liverpool Health Campus Timeline

1995

Wellcome Trust Tropical Centre

The Wellcome Trust Tropical Centre (WTTC) was established in 1995 as a collaborative centre between the Liverpool School of Tropical Medicine and the University of Liverpool. The Centre was funded by the Wellcome Trust and is located in the Old Royal Liverpool Infirmary. The WTTC provides support for international research in a wide range of specialist areas and is instrumental in encouraging applicants and recruiting for clinical and non-clinical Wellcome Trust Fellowships in Tropical Medicine. The WTTC is also primarily responsible for providing logistical, financial and project support for Fellowships and to several international sites. The main site supported is the Malawi Liverpool Wellcome Trust Research Programme based in Blantyre, Malawi, but there are a number of other overseas sites including Kenya, Tanzania, Zambia and India. The present Director of the WTTC is Professor David Lalloo.

www.liverpoolwttc.org.uk/

1996

The Cancer Research UK Liverpool Cancer Trials Unit

The Cancer Research UK Liverpool Cancer Trials Unit (LCTU) is principally involved in phase III and large randomised phase II cancer trials with core infrastructure posts and running costs. It is one of only eight CR-UK core funded phase III Cancer Trials Units. The LCTU has a strong relationship with collaborative NHS R&D Departments including those at the Royal Liverpool University Hospital, Clatterbridge Centre for Oncology and University Hospital Aintree. It also provides trial, medical statistics and bioinformatics consultancy and support to University and NHS colleagues led by Dr Trevor Cox with a team of eight medical statisticians and bioinformaticians. The Director is Professor John Neoptolemos.

www.lctu.org.uk

 

1997

Research Institute for Sport & Exercise Sciences, Liverpool John Moores University

The Research Institute for Sport and Exercise Sciences (RISES) supports research activity broadly aligned to the following themes: Chronobiology, Human Performance (including biomechanics), and Exercise and Health. The RISES Cardiovascular Science groups have established fundamental new information regarding mechanisms of cardiac and skeletal myocyte death, replenishment and function, and additionally concerning forms of exercise that can cause cardiac fatigue and damage. In January 2010 RISES moved into the state-of-the-art Tom Reilly Building with bespoke and specialist research and teaching facilities including a temporal isolation laboratory, a stem cell and molecular physiology laboratory, plus a unique movement function research laboratory for clinical biomechanics studies alongside a 50 metre runway.

www.ljmu.ac.uk/sps/RISES/index.htm

 

1998

Centre for Public Health, Liverpool John Moores University

The Centre for Public Health is a World Health Organization (WHO) Collaborating Centre for Violence Prevention. It works with WHO to support and develop violence prevention in the UK and internationally, through the provision of evidence reviews and original research. The Centre also hosts the Department of Health funded North West Public Health Observatory, which is the lead UK Observatory for public health intelligence on alcohol, drugs and violence. The work of the Centre demonstrates how the effective use of health surveillance data can inform behavioural research and health promotion or treatment interventions, and how these can play a role in shaping policy.

www.cph.org.uk

 

2004

Clinical Eye Research Centre

The Clinical Eye Research Centre (CERC) of St. Paul’s Eye Unit is a purpose built facility aiming to develop new methods of detecting, assessing, treating and ultimately preventing eye disease. The ethos is for “high tech, low volume” research in a patient centred environment. The CERC bridges laboratory and routine clinical practice in eye and vision science with clinical and non-clinical scientists coming together from a range of disciplines to study mechanisms and treatment of eye diseases. Funding is from Trust, University, NHS R&D and external non-commercial and commercial income. Programs comprise age-related macular degeneration, ocular oncology, diabetic retinopathy, surgical retina, ocular structure and function, visuomotor and cornea and refractive surgery. The CERC has contributed to the strategic development of biotechnology through engagement with therapeutic and product development programmes run by the NHS, development companies and the pharmaceutical industry. Specific areas include advanced therapies for eye diseases, image analysis, automated detection of disease, clinical trials and new approaches to investigating mechanisms of disease.

The Marie Curie Palliative Care Institute Liverpool

The Marie Curie Palliative Care Institute Liverpool (MCPCIL) was established in November 2004 by Marie Curie Cancer Care, the University of Liverpool and the Royal Liverpool & Broadgreen University Hospitals NHS Trust. The Institute has a multi-professional profile and is under the leadership of John Ellershaw, Professor of Palliative Medicine at the University of Liverpool, Medical Director at the Marie Curie Hospice, Liverpool and Clinical Director of the Specialist Palliative Care Directorate at the Royal Liverpool & Broadgreen University Hospitals NHS Trust.

The MCPCIL is a leading organisation in the field of palliative care, with a specific focus on end of life care and care of the dying. The work of the Institute is directed towards making a real and sustained difference to patient care, from bedside to policy, and has achieved through its research and innovation £4 million grant portfolio.

www.liverpool.ac.uk/mcpcil

 

2005

Centre for Health and Social Care Informatics, Liverpool John Moores University

The Centre for Health and Social Care Informatics promotes the development, application and use of informatics within healthcare (and also social care and other health-related disciplines). The Centre adopts a multidisciplinary approach in order for its research to concentrate on developing and implementing IT solutions in both clinical and management disciplines. It draws upon expertise in a range of disciplines, including the health sciences, computing and mathematical sciences, engineering and sport science.

www.ljmu.ac.uk/CHaSCI/81279.htm

 

2006

National Centre for Zoonosis Research

The National Centre for Zoonosis Research (NCZR) is a combined venture of the universities of Liverpool and Lancaster, the Health Protection Agency and the Veterinary Laboratories Agency.

The Centre is physically hosted by the University of Liverpool at Leahurst Campus, the field station of the University’s Veterinary School, on the Wirral, but it is the hub for collaborative research across the UK and further afield.

The NCZR is a research network which seeks to reduce the impact of zoonotic disease in the UK and internationally. The Centre promotes zoonosis prevention and control by building research collaborations, coordinating and arranging research activity, facilitating training and enhancing communication.

www.zoonosis.ac.uk

Institute for Health Research, Liverpool John Moores University

The Institute for Health Research (IHR) provides direction and focus to all health research at LJMU and aims to promote, maintain and reward excellence in the quality of health research and ensure that its health and health-related research is world class. It operates as research networks whose boundaries extend far beyond the University structure to engage and collaborate with external organisations, health and social care professionals, and partners in industry. The main areas of research activity encompassed by the networks are: Medical Sciences and Therapeutics; Organisation and Delivery of Health Services & Public Health; Quality of Life.

www.ljmu.ac.uk/ihr

 

2007

Centre for Materials Discovery

The Centre for Materials Discovery (CMD) at University of Liverpool provides research and knowledge transfer services to academia and industry in the area of high throughput materials discovery. The focus of CMD is to use state-of-the-art robotics and automation technologies for the accelerated discovery of new functional materials in applications such as energy, health, home and personal care. Working closely with other universities in the North West, the centre aims to provide access to leading research, training for industry personnel, and world-class facilities such as robotics and advanced ICT. It is accessible to all businesses across the North West and UK and has enabled small, medium, and large industries across a range of sectors to move rapidly into the next generation of materials science.

www.liverpool.ac.uk/materials-discovery

Liverpool Experimental Cancer Medicine Centre

The NIHR and Cancer Research UK Liverpool Experimental Cancer Medicine Centre (LECMC) runs an extensive programme of biobanking, biomarker studies, new drug discovery, translational research and early-phase clinical trials. Established in 2007 it has core infrastructure posts, equipment and running costs with dedicated laboratories for sample collection and analyses to the standard of Good Clinical Laboratory Practice (GCLP). The LECMC hosts over 60 clinical trials, covering 12 distinct cancer types, of which 90% are phase I or II. A significant number of these trials have associated-sample collection or sample analysis.

www.lctu.org.uk/lecmc

 

2008

Centre for Tropical & Infectious Diseases

The Centre for Tropical and Infectious Diseases is a £23 million state of the art facility which puts LSTM at the forefront of infectious disease research and adds to the growing importance of the North West of England in worldwide biotechnology.

It brings together, under one roof for the first time, a multidisciplinary team of scientists capable of taking a scientific idea from ‘molecule to man’ and is at the very heart of LSTM’s long term plans to generate products to directly improve health in the developing world.

Research undertaken in CTID addresses new challenges in the treatment of infectious diseases through drug and vaccine design and development, initiation and management of clinical trials, pesticide and vector control design and development and cell and molecular biology pathogen research. The building provides 7,800 square metres of laboratory, write up and office space over four floors and has brought 1,800 square metres of brownfield land back into productive use. The building was opened by HRH The Princess Royal in 2008.

www.lstmliverpool.ac.uk/research/

MRC Centre for Drug Safety Science

The MRC-funded Centre for Drug Safety Science was established as a joint venture between the Universities of Liverpool and Manchester to bring together a critical mass of knowledge and technologies in order to advance our understanding of Adverse Drug Reactions and acts as a fulcrum for fostering collaborative pre-competetive research between academia, the pharmaceutical industry and the drug regulators. Its remit is to understand the fundamental mechanisms of clinically-important Adverse Drug Reactions with the overall aim of preventing such reactions by improved drug selection, improved drug design and more informed patient selection. The success of the Centre is built on a cutting-edge bioanalytical platform that combines pharmacology, medicinal chemistry, structural biology, proteomics, metabolomics, molecular biology, immunology and genetics, and importantly allows for the quantification of both chemistry and biology in the same patient sample or experiment.

www.liverpool.ac.uk/drug-safety

Liverpool NMR Centre for Structural Biology

The Liverpool NMR Centre for Structural Biology, located in purpose-built accommodation adjacent to the School’s Life Sciences and Biosciences buildings, houses one of the largest Nuclear Magnetic Resonance (NMR) spectrometers in the UK.

The Centre supports a wide range of projects including studies in cancer, malaria, cardiovascular disease, and Alzheimer’s Disease with the main focus on the understanding of the molecular basis of these disease states. There is a strong commitment to use a combination of biological, chemical and computational approaches in our research. Included in these objectives is the development of enabling technologies that will assist with the target and drug discovery processes. The Centre is directed by Professor Lu-Yun Lian.

www.liverpool.ac.uk/integrative-biology

The Centre for Genomic Research

The Centre for Genomic Research (CGR) conducts world-class research at the leading edge of genomic technologies and data analyses. With a diverse portfolio of projects ranging from metagenomics, plant and animal studies to cancer genomics and human genetics, the CGR is constantly exploring new technologies and making innovative approaches and applications available to researchers investigating fundamental and applied biological processes. The CGR receives core funding from the Medical Research Council (MRC), the Natural Environment Research Council (NERC) and the University of Liverpool to provide genomics services and bioinformatics support. It is one of four MRC genomics hubs in the UK alongside Cambridge, Edinburgh and Oxford, and one of 4 nodes in NERC Bioanalysis Facility, both of which establish the CGR as a key component of the UK national research infrastructure, and reinforcing the Centre’s growing reputation as a centre of excellence for genomic technologies and data analyses. In addition, the Centre has a portfolio of project grants from the BBSRC and other UK and European funding agencies, with an increasing number of collaborative service projects with partners in academia and industry providing a third income stream. Although it is run on a cost-recovery basis, the Centre is established as a not-for-profit venture with all proceeds reinvested into maintaining capability at the leading edge of science.

www.liv.ac.uk/genomic-research/

2009

Dental Research Facility

Liverpool University Dental Hospital, part of the Royal Liverpool and Broadgreen University Hospitals NHS Trust, is closely integrated with the University’s School of Dentistry. The School of Dental Sciences is committed to high quality research that will enhance both the academic and clinical aspects of Clinical Dentistry.

The School has a range of research expertise that spans both basic and applied clinical sciences. The central strategy for the next 5-10 years will be to build on existing strengths, further integrating our research at both the Faculty and University level to provide a thriving research environment. During the last RAE period, members of staff in the School received in excess of £7 million in grant income and published over 650 publications.

The new Research Wing, a first rate facility, demonstrates the University of Liverpool’s commitment to cutting-edge research within the School of Dental Sciences.

NIHR Biomedical Research Centre in Microbial Diseases

The National Institute of Health Research (NIHR) conferred the status of Specialist Biomedical Research Centre (BRC) in Microbial Diseases to the partnership of the Royal Liverpool & Broadgreen University Hospitals NHS Trust, the University of Liverpool and the Liverpool School of Tropical Medicine.

The key aims of Liverpool BRC are: to reduce the burden of infection on the NHS; to be a global health-academic player in addressing; the challenge of infection; to be a pioneer in the development of new drugs and diagnostic tools in infection.

The BRC’s ground-breaking translational research is based around a managed portfolio of research projects. Themes focus on identified healthcare priorities that build on strengths in research and clinical excellence within the NHS, the University of Liverpool and Liverpool School of Tropical Medicine. BRC research themes are: Safety of Antimicrobials; Sexual Health; Community and Hospital Acquired Infections; Pulmonary Infections.

The BRC also features a number of state-of-the-art facilities available to support commercial and non-commercial studies. Clinical Research Facility provides an onsite patient focused clinical environment, comprising interview and examination rooms, 6 beds and clinical support to meet regulatory needs for first-in-man clinical trials. Medical Microbiology Facility for identification and safe handling of bacteria. Bioanalytical Facility, including a Liquid Chromatography-Mass Spectrometry system to measure drug levels and other small molecules at low concentrations. Data and a Sample Repository for human samples and microbials to allow a comprehensive investigation of pathogenesis at the level of mRNA, DNA, protein and whole cells.

Liverpool CR-UK Cancer Research Centre

The Cancer Research UK Centre formally came into being in July 2009 and is one of only 15 or such centres. The Liverpool Centre has a focus on pancreatic, head and neck, haematological, paediatric and lung malignancies as well as melanoma and palliative cancer care and also aiming to enhance treatment using radiotherapy and surgical oncology. Core funding provides infrastructure posts to promote integrative cancer research in the University of Liverpool and collaborative NHS partners across Liverpool and Merseyside. It includes project pump priming support and a funded programme for clinical and non-clinical PhD training posts. The Department of Cancer Medicine is the major component of the Liverpool CR-UK Centre which is serving as a focus for the reconfiguration of cancer services and research in Liverpool and the region.

www.liverpoolcancercentre.org.uk

Wolfson Centre for Personalised Medicine

The Wolfson Centre for Personalised Medicine, one of only three in the world, opened in November 2009. It was funded by the University and a £2 million donation from the Wolfson Trust to refurbish and kit out an area of the Liverpool Royal Infirmary to a standard consistent with a listed building. It has a state of the art archiving system with robots, with 300,000 bar coded samples. Their genotyping platform can process 100,000 per day.

The aim of Liverpool’s research programme – the largest of its kind in the UK – is to define the mechanisms of variability in drug response and translate these findings into clinical care. It works in conjunction with the Biomedical Research Centre in Microbial Diseases.

www.liverpool.ac.uk/pharmacogenetics/centre_for_personalised_medicine

 

2010

Liverpool NIHR Pancreas Biomedical Research Unit

The Liverpool NIHR Pancreas Biomedical Research Unit (PBRU), which is based at the Royal Liverpool University Hospital, is a dedicated translational research unit for pancreatic diseases, such as acute and chronic pancreatitis and pancreatic cancer. The PBRU is built around the world class excellence of pancreas research in Liverpool, incorporating the strengths of the Royal Liverpool and Broadgreen University Hospitals Trust (RLBUHT) and University of Liverpool which include: RLBUHT Research and Development, Liverpool BRC, Liverpool CR-UK Centre, Liverpool Cancer Trials Unit (LCTU), and Liverpool Experimental Cancer Medicine Centre (LECMC). The PBRU has well established links with various industrial partners concerned with diagnostic and drug development as well as early phase clinical trials. The PBRU is carrying out an ambitious research programme, focused on: drug discovery and the development of new interventions; application of new diagnostic and imaging strategies; validation of new biomarkers and screening protocols. The Executive Director of the PBRU is Professor Robert Sutton and the Scientific Director is Professor John Neoptolemos.

www.pancreasbru.co.uk

2012

Liverpool Health Partners

The Royal Liverpool & Broadgreen University Trust has partnered with eight other healthcare organisations to create Liverpool Health Partners (LHP). The objective of LHP is to create a strategic partnership to deliver health gain and to pursue excellence in the delivery of healthcare, research and education.

The LHP has been established to demonstrate international excellence in research, supported by clinical services, which can be developed in a coordinated way across the local health economy.

Research: LHP brings together clinical and scientific expertise to develop truly world-leading research that draws on the strengths from within each of the founding partner organisations as well as an increasing network of member organisations from across the region.

Education: LHP has a central role in coordinating high quality and efficient collaboration between Merseyside’s academic institutions and prominent teaching hospitals in order to meet the educational and training needs of the healthcare workforce.

Healthcare: LHP offers a broad and comprehensive range of healthcare services that includes both acute and non-acute specialities.

Industry & Innovation: LHP is well positioned to take advantage of the localised strengths in innovation and industry. The North West is rated as one of the top three biomedical clusters in the UK, based on a major pharmaceutical presence, rapidly expanding biotechnology community, many healthcare technology companies and a strong analytical and clinical supply presence.

www.liverpoolhealthpartners.org.uk

Investment Opportunities Available from 2012 onwards

The HealthCampus opportunity is enhanced by its proximity to the universities, LSTM, Liverpool Science Park and the MerseyBio incubator. Development of the new hospital will be supplemented by additional investment in new life science research laboratories by UoL and LSTM.

The Liverpool Life Sciences Accelerator will be the next major investment on the Health Campus site.

2013

Covance & Royal Liverpool University Hospital Alliance

Covance Inc., a leading global drug development services company, and the Royal Liverpool and Broadgreen University Hospitals NHS Trust have entered into a five-year exclusive agreement to work together in conducting early clinical trials at the Royal Liverpool University Hospital on behalf of biotechnology and pharmaceutical companies.
This alliance provides a unique opportunity to build innovative solutions for high-quality early clinical research in a safe and regulated environment at a time when more sponsors are looking to develop studies that call for the recruitment of healthy volunteers and patients.

As part of its 2017 expansion plans, the Trust will look to expand the clinical research unit at the Royal Liverpool University Hospital and further maximize early patient benefits from research at its facility. This expansion will help establish the Royal Liverpool University Hospital and the region as a major biosciences hub. By increasing focus on early clinical research, the Trust will give patients the opportunity to participate in early clinical research for potentially new breakthrough medicines.

www.rlbuht.nhs.uk/Research%20Development%20and%20Innovation/Pages/CRU%20-%20Homepage.aspx

MHRA Phase 1 Accreditation First in Human Clinical Trials

The Covance Royal Liverpool Clinical Research Unit (CLRCRU) at the Royal Liverpool University Hospital has become the first NHS facility in England to be granted Medicines and Healthcare Products Regulatory Agency (MHRA) standard and supplementary Phase I Accreditation.

MHRA Phase 1 Accreditation will allow the Trust to perform clinical trials in patients with some of the newest treatments under evaluation, to some of the most rigorous set of standards in the world. It will help provide patients with greater access to the very latest drugs and technologies and will bring economic benefits to the city of Liverpool as a centre for global healthcare research.

The MHRA Phase I Accreditation scheme was introduced to improve the safety of clinical research volunteers and assesses the capability of the clinical research unit based on facilities, procedures, training and experience of staff.

This accreditation will allow the Royal, together with the University of Liverpool, the Liverpool School of Tropical Medicine and other local NHS Trusts that comprise Liverpool Health Partners (LHP), to be at the forefront of clinical developments and drug trials to prevent illnesses, provide faster diagnoses and find new treatments. LHP will make Liverpool a centre for clinical research and excellence, to ensure the benefits of medical research breakthroughs are directly passed onto patients in the region.

www.rlbuht.nhs.uk/Pages/NewsDetail.aspx?CommonId=107

2017

Liverpool Life Sciences Accelerator

Find out more about the The Accelerator

2018

New Hospital

The existing Royal Liverpool University Hospital is to be replaced by a new hospital, built on part of the current site. The business case is fully supported locally and has been approved by the Department of Health and HM Treasury and a private sector partner has been chosen. Construction commenced in early 2014 and the hospital will open in 2018.

The new Royal is designed to deliver best in class performance, with an excellent patient environment (including 100% single bedrooms), improved clinical productivity, sustainable design and construction and a landmark public building at the gateway to the city.

www.rlbuht.nhs.uk/The%20New%20Royal/Pages/V2%20New%20Royal%20Home.aspx

2018-2020

Site Development

Demolition of the old hospital facilities will quickly be followed by completion of the site infrastructure and a newly landscaped site.

The Trust’s outline planning permission for the new Royal includes up to 100,000m2 of further health related development on the site, taking the form of new city blocks around a landscaped public green space. This enables the creation of the Health Campus.

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